現在のページ:TOPページ診療科血液・腫瘍内科 ≫ 疾患と症例|、診療実績

血液・腫瘍内科

対象疾患と診療実績

対象疾患

血液疾患: 白血病、悪性リンパ腫、再生不良性貧血、骨髄異形成症候群、血球貪食症候群、ランゲルハンス細胞組織球症、血友病など
固形腫瘍:神経芽腫、肝芽腫、ウィルムス腫瘍、横紋筋肉腫、網膜芽腫、脳腫瘍、骨軟部腫瘍など

小児がん拠点病院として小児科領域のすべての悪性腫瘍の治療の治療に取り組んでいます。
がんゲノム医療連携病院としてがんゲノム医療拠点病院と連携し、がんゲノム情報に基づいた難治再発例の個別化治療や遺伝性腫瘍の診断に取り組んでいます。

日本小児がん研究グループ(JCCG)に所属しており、基本的には白血病、悪性リンパ腫、各種固形腫瘍等については多施設共同研究の成果に基づいた同グループの定める全国共通のプロトコールで治療を行なっています。

また、日本血栓止血学会認定施設、及び日本免疫不全・自己炎症学会連携施設でもあり、血友病をはじめとする出血性疾患、原発性免疫不全症などにも対応します。



診療実績

2019年の新規症例は120例(白血病等の造血器腫瘍42例、神経芽腫、脳腫瘍等の固形腫瘍78例)で全国でも有数の症例数を誇っています。難治例については造血細胞移植も考慮します。

また隣接する神戸陽子線センターと連携して、2018年3月から小児・AYAがんに対する陽子線治療を開始し、以降積極的に推進しています。鎮静や化学療法の併用を必要とする小児例を中心に小児・AYAがんに対して陽子線治療を実施しており、放射線治療後の二次がんや臓器障害等の晩期障害の低減が期待されます。2019年に行った陽子線治療数は66例であり、豊富な治療経験を有しています。


造血幹細胞移植数(2003-2020年)

小児がん医療センターには専用の完全無菌室(class 100)4床を備えており、難治例に対しては必要に応じて造血幹細胞移植を行なっています。

造血細胞移植認定医7名を含む14名の血液・腫瘍内科専任医師に加えて、看護師、薬剤師、臨床心理士、社会福祉士、管理栄養士、臨床検査技師、精神科医、形成外科医、歯科医師、緩和ケアチーム(麻酔科医)、移植コーディネーター等の多職種で構成される造血幹細胞移植カンファレンスで課題を解決しながら移植技術の向上に努めています。

当院では2003年に骨髄移植推進財団および日本さい帯血バンクネットワークの移植認定施設となりましたが、これ以降の移植件数(2003年―2020年)は同種移植・自家移植を併せて321件(同種移植187件、自家移植134件)です。


業績


業績


―2021年―


The incidence of symptomatic osteonecrosis is similar between Japanese children and children in Western countries with acute lymphoblastic leukaemia treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol. Moriya K, Imamura T, Katayama S, Kaino A, Okamoto K, Yokoyama N, Uemura S, Kitazawa H, Sekimizu M, Hiramatsu H, Usami I, Ishida H, Hasegawa D, Hama A, Moriya-Saito A, Sato A, Sasahara Y, Suenobu S, Horibe K, Hara J; Japan Association of Childhood Leukemia Study Group (JACLS). Br J Haematol. 2021 Dec 8. doi: 10.1111/bjh.17988.


Effect of Monoammonium Glycyrrhizinate on the Development of Hepatotoxicity After Initial Intrathecal Chemotherapy for Leukemia. Kishimoto K, Hasegawa D, Uemura S, Nakamura S, Kozaki A, Saito A, Ishida T, Mori T, Kosaka Y. Anticancer Res. 2021 Dec;41(12):6231-6236. doi: 10.21873/anticanres.15443.


Prospective validation of the provisional entity of refractory cytopenia of childhood, proposed by the World Health Organization. Hama A, Hasegawa D, Manabe A, Nozawa K, Narita A, Muramatsu H, Kosaka Y, Kobayashi M, Koh K, Takahashi Y, Watanabe K, Ohara A, Ito M, Kojima S. Br J Haematol. 2021 Nov 3. doi: 10.1111/bjh.17921.


Therapeutic options for CTLA-4 insufficiency. Egg D, Rump IC, Mitsuiki N, Rojas-Restrepo J, Maccari ME, Schwab C, Gabrysch A, Warnatz K, Goldacker S, Patiño V, Wolff D, Okada S, Hayakawa S, Shikama Y, Kanda K, Imai K, Sotomatsu M, Kuwashima M, Kamiya T, Morio T, Matsumoto K, Mori T, Yoshimoto Y, Dybedal I, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Lorenz HM, Sullivan KE, Heimall J, Moutschen M, Litzman J, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Snapper S, Giulino-Roth L, Svaton M, Platt CD, Hambleton S, Neth O, Gosse G, Reinsch S, Holzinger D, Kim YJ, Bakhtiar S, Atschekzei F, Schmidt R, Sogkas G, Chandrakasan S, Rae W, Derfalvi B, Marquart HV, Ozen A, Kiykim A, Karakoc-Aydiner E, Králíčková P, de Bree G, Kiritsi D, Seidel MG, Kobbe R, Dantzer J, Alsina L, Armangue T, Lougaris V, Agyeman P, Nyström S, Buchbinder D, Arkwright PD, Grimbacher B. J Allergy Clin Immunol. 2021 Jun 7:S0091-6749(21)00891-5. doi: 10.1016/j.jaci.2021.04.039.


Prognostic value of the revised International Prognostic Scoring System five-group cytogenetic abnormality classification for the outcome prediction of hematopoietic stem cell transplantation in pediatric myelodysplastic syndrome. Yamamoto S, Kato M, Watanabe K, Ishimaru S, Hasegawa D, Noguchi M, Hama A, Sato M, Koike T, Iwasaki F, Yagasaki H, Takahashi Y, Kosaka Y, Hashii Y, Morimoto A, Atsuta Y, Hasegawa D, Yoshida N. Bone Marrow Transplant. 2021 Sep 10. doi: 10.1038/s41409-021-01446-z.


Clinical characteristics and risk factors for mortality in children with Pseudomonas aeruginosa bacteraemia: A retrospective review at a paediatric tertiary centre. Kishimoto K, Kasai M, Kawamura N, Otake S, Hasegawa D, Kosaka Y. J Paediatr Child Health. 2021 Jun 25. doi: 10.1111/jpc.15634.


Phase III study of palonosetron for prevention of chemotherapy-induced nausea and vomiting in pediatric patients. Hara J, Kosaka Y, Koh K, Matsumoto K, Kumamoto T, Fujisaki H, Ishida Y, Suzuki R, Mochizuki S, Goto H, Yuza Y, Koga Y. Jpn J Clin Oncol. 2021 May 21:hyab079. doi: 10.1093/jjco/hyab079.


Limited correlation between tumor markers and minimal residual disease detected by seven neuroblastoma‑associated mRNAs in high‑risk neuroblastoma patients. Uemura S, LS Kyaw, Twin KKM, Nakatani N, Ishida Toshiaki, Yamamoto N, Tamura A, Saito A, Mori T, Hasegawa D, Kosaka Y, Nino N, Nagano C, Takafuji S, Iijima K, Nishimura N. Molecular and Clinical Oncology 15: 137, 2021


Minimal residual disease in high-risk neuroblastoma shows a dynamic and disease burden-dependent correlation between bone marrow and peripheral blood. Lin KS, Uemura S, Thwin KKM, Nakatani N, Ishida T, Yamamoto N, Tamura A, Saito A, Mori T, Hasegawa D, Kosaka Y, Nino N, Nagano C, Takafuji S, Iijima K, Nishimura N. Transl Oncol. 2021 May 13;14(8):101019. doi: 10.1016/j.tranon.2021.101019. Online ahead of print.


Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines. Mizumoto M, Fuji H, Miyachi M, Soejima T, Yamamoto T, Aibe N, Demizu Y, Iwata H, Hashimoto T, Motegi A, Kawamura A, Terashima K, Fukushima T, Nakao T, Takada A, Sumi M, Oshima J, Moriwaki K, Nozaki M, Ishida Y, Kosaka Y, Ae K, Hosono A, Harada H, Ogo E, Akimoto T, Saito T, Fukushima H, Suzuki R, Takahashi M, Matsuo T, Matsumura A, Masaki H, Hosoi H, Shigematsu N, Sakurai H. Cancer Treat Rev. 2021 Apr 16;98:102209. doi: 10.1016/j.ctrv.2021.102209. Online ahead of print.


Muscle mass change during chemotherapy in children with high-risk neuroblastoma: a retrospective case series of 24 patients. Nakamura N, Kishimoto K, Ishida T, Nakamura S, Tamura A, Kozaki A, Saito A, Hasegawa D, Kosaka Y. Eur J Pediatr. 2021 May 10. doi: 10.1007/s00431-021-04106-y. Online ahead of print.


Effect of high-dose chemotherapy plus stem cell rescue on the survival of patients with neuroblastoma modified by MYCN gene gain/amplification and remission status: a nationwide registration study in Japan. Saito Y, Urashima M, Takahashi Y, Ogawa A, Kiyotani C, Yuza Y, Koh K, Watanabe K, Kosaka Y, Goto H, Kikuta A, Okada K, Koga Y, Fujimura J, Inoue M, Sato A, Atsuta Y, Matsumoto K. Bone Marrow Transplant. 2021 Apr 28. doi: 10.1038/s41409-021-01303-z. Online ahead of print.


Effect of extramedullary disease on allogeneic hematopoietic cell transplantation for pediatric acute myeloid leukemia: a nationwide retrospective study. Sakaguchi H, Miyamura T, Tomizawa D, Taga T, Ishida H, Okamoto Y, Koh K, Yokosuka T, Yoshida N, Sato M, Noguchi M, Okada K, Hori T, Takeuchi M, Kosaka Y, Inoue M, Hashii Y, Atsuta Y.Bone Marrow Transplant. 2021 Mar 10. doi: 10.1038/s41409-021-01250-9.


Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group. Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Riku Y, Akagi A, Oohashi W, Shofuda T, Yoshioka E, Sato Y, Taga T, Naruke Y, Ando R, Hasegawa D, Yoshida M, Sakaida T, Okada N, Watanabe H, Ozeki M, Arakawa Y, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y. Brain Tumor Pathol. 2021 Mar 11. doi: 10.1007/s10014-021-00396-0.


Prednisolone poor response is not an indication for HSCT in pediatric B-cell precursor acute lymphoblastic leukemia in first remission: results from JACLS ALL-02 study. Ishida H, Yano M, Hasegawa D, Hori T, Hashii Y, Kato K, Deguchi T, Saito A, Sato A, Hori H, Horibe K, Imamura T. Int J Hematol. 2021 Feb 28. doi: 10.1007/s12185-021-03110-0.


Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome. Taga T, Tanaka S, Hasegawa D, Terui K, Toki T, Iwamoto S, Hiramatsu H, Miyamura T, Hashii Y, Moritake H, Nakayama H, Takahashi H, Shimada A, Taki T, Ito E, Hama A, Ito M, Koh K, Hasegawa D, Saito AM, Adachi S, Tomizawa D. Leukemia. 2021 Feb 15. doi: 10.1038/s41375-021-01157-w.


Clinical outcome of patients with recurrent or refractory localized Ewing's sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group. Umeda K, Miyamura T, Yamada K, Sano H, Hosono A, Sumi M, Okita H, Kumamoto T, Kawai A, Hirayama J, Jyoko R, Sawada A, Nakayama H, Hosoya Y, Maeda N, Yamamoto N, Imai C, Hasegawa D, Chin M, Ozaki T; Japan Ewing Sarcoma Study Group. Cancer Rep (Hoboken). 2021 Jan 16:e1329. doi: 10.1002/cnr2.1329.


Seroepidemiological Survey of the Antibody for Severe Acute Respiratory Syndrome Coronavirus 2 with Neutralizing Activity at Hospitals: A Cross-sectional Study in Hyogo Prefecture, Japan. Furukawa K, Arii J, Nishimura M, Tjan LH, Lystia Poetranto A, Ren Z, Aktar S, Huang JR, Sutandhio S, Kurahashi Y, Nishino A, Shigekuni S, Takeda Y, Uto K, Matsui K, Sato I, Inui Y, Endo K, Kosaka Y, Oota T, Saegusa J, Mori Y. JMA J. 2021 Jan 29;4(1):41-49. doi: 10.31662/jmaj.2020-0094. Epub 2021 Jan 14.


Early elevation of factor IX level in japanese brothers with Haemophilia B Leyden who are carrying c. -35 g > a mutations in the promoter region of F9. Tamura A, Shinozawa K, Uemura S, Nakamura S, Fujiwara T, Tahara T, Yamamoto N, Saito A, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Muramatsu T, Amano K, Fukutake K, Kosaka Y. Haemophilia. 2021 Jan 11. doi: 10.1111/hae.14248.


AFP-L3 as a Prognostic Predictor of Recurrence in Hepatoblastoma: A Pilot Study. Kawahara I, Fukuzawa H, Urushihara N, Kosaka Y, Kuroda Y, Fujieda Y, Takeuchi Y, Uemura K, Iwade T, Samejima Y, Morita K, Maeda K. J Pediatr Hematol Oncol. 2021 Jan;43(1):e76-e79. doi: 10.1097/MPH.0000000000001971.

―2020年―


Prognostic and therapeutic factors influencing the clinical outcome of metastatic Ewing sarcoma family of tumors: A retrospective report from the Japan Ewing Sarcoma Study Group. Umeda K, Miyamura T, Yamada K, Sano H, Hosono A, Sumi M, Okita H, Kamio T, Maeda N, Fujisaki H, Jyoko R, Watanabe A, Hosoya Y, Hasegawa D, Takenaka S, Nakagawa S, Chin M, Ozaki T; Japan Ewing Sarcoma Study Group. Pediatr Blood Cancer. 2020 Dec 19:e28844. doi: 10.1002/pbc.28844.


Limited correlation between tumor markers and minimal residual disease detected by seven neuroblastoma-associated mRNAs in high-risk neuroblastoma patients. Uemura S, Lin KS, Thwin KKM, Nakatani N, Ishida T, Yamamoto N, Tamura A, Saito A, Mori T, Hasegawa D, Kosaka Y, Nino N, Nagano C, Takafuji S, Iijima K, Nishimura N. Molecular and Clinical Oncology 2020 in press.


Pulmonary hypertension related to hereditary folate malabsorption in an infant. Miyashita N, Kurosawa H, Yamashita Y, Miki Y, Ishida T. Pediatr Int. 2020 Sep 7. doi: 10.1111/ped.14266.


Low multiplication value of absolute monocyte count and absolute lymphocyte count at diagnosis may predict poor prognosis in neuroblastoma. Tamura A, Inoue S, Mori M, Noguchi J, Nakamura S, Saito A, Kozaki A, Ishida T, Sadaoka K, Hasegawa D, Kosaka Y, Miyanishi M. Front Oncol. 2020 Oct 2;10:572413. doi: 10.3389/fonc.2020.572413.


Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia. Ueno H, Yoshida K, Shiozawa Y, Nannya Y, Iijima-Yamashita Y, Kiyokawa N, Shiraishi Y, Chiba K, Tanaka H, Isobe T, Seki M, Kimura S, Makishima H, Nakagawa MM, Kakiuchi N, Kataoka K, Yoshizato T, Nishijima D, Deguchi T, Ohki K, Sato A, Takahashi H, Hashii Y, Tokimasa S, Hara J, Kosaka Y, Kato K, Inukai T, Takita J, Imamura T, Miyano S, Manabe A, Horibe K, Ogawa S, Sanada M. Blood Adv. 2020 Oct 27;4(20):5165-5173. doi: 10.1182/bloodadvances.2019001307.


CNS Low-grade Diffusely Infiltrative Tumors With INI1 Deficiency, Possessing a High Propensity to Progress to Secondary INI1-deficient Rhabdoid Tumors. Nobusawa S, Nakata S, Nakano Y, Kawamura A, Yoshida M, Tamura A, Hasegawa D, Kosaka Y, Ito I, Watanabe R, Oishi T, Hayashi N, Ishikawa E, Sakamoto N, Okura N, Murakami C, Ichimura K, Hirato J, Yokoo H. Am J Surg Pathol. 2020 Nov;44(11):1459-1468. doi: 10.1097/PAS.0000000000001520.


Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia. Koyamaishi S, Kamio T, Kobayashi A, Sato T, Kudo K, Sasaki S, Kanezaki R, Hasegawa D, Muramatsu H, Takahashi Y, Sasahara Y, Hiramatsu H, Kakuda H, Tanaka M, Ishimura M, Nishi M, Ishiguro A, Yabe H, Sarashina T, Yamamoto M, Yuza Y, Hyakuna N, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Miyano S, Ogawa S, Toki T, Terui K, Ito E. Bone Marrow Transplant. 2020 Sep 18. doi: 10.1038/s41409-020-01056-1.


Long-term outcome in patients with Fanconi anemia who received hematopoietic stem cell transplantation: A retrospective nationwide analysis. Yabe M, Morio T, Tabuchi T, Tomizawa D, Hasegawa D, Ishida H, Yoshida N, Koike T, Takahashi Y, Koh K, Okamoto Y, Sano H, Kato K, Kanda Y, Goto H, Takita J, Miyamura T, Noguchi M, Kato K, Hashii Y, Astuta Y, Yabe H. Int J Hematol. 2020 Sep 19. doi: 10.1007/s12185-020-02991-x.


Attempts to optimize post-induction treatment in childhood acute myeloid leukemia without core binding factors: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG). Hasegawa D, Tawa A, Tomizawa D, Watanabe T, Saito MA, Kudo K, Taga T, Iwamoto S, Shimada A, Terui K, Miritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Miyachi H, Horibe K, Nakahata T, Adachi S. Pediatr Blood Cancer. 2020 Sep 4:e28692. doi: 10.1002/pbc.28692.


Outcomes of Local Radiation and Intensified Combined Intrathecal Methotrexate and High-dose Chemotherapy for Intracranial Germ Cell Tumors. Yamasaki K, Okada K, Soejima T, Kosaka Y, Nagashima T, Hara J. J Pediatr Hematol Oncol. 2020 May 8. doi: 10.1097/MPH.0000000000001820.


Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. Aoki T, Takahashi H, Tanaka S, Shiba N, Hasegawa D, Iwamoto S, Terui K, Moritake H, Nakayama H, Shimada A, Koh K, Goto H, Kosaka Y, Saito AM, Horibe K, Kinoshita A, Tawa A, Taga T, Adachi S, Tomizawa D. Br J Haematol. 2020 Apr 26. doi: 10.1111/bjh.16656.


Pharmacokinetic analysis for model-supported therapeutic drug monitoring of busulfan in Japanese pediatric hematopoietic stem cell transplantation recipients. Kishimoto K, Hasegawa D, Irie K, Oksada A, Tamura A, Yamamoto N, Saito A, Kozaki A, Ishida T, Fukushima S, Kosaka Y. Pediatr Transplant. 2020 Mar 20:e13696. doi: 10.1111/petr.13696.


Risk-adjusted therapy for pediatric non-T cell ALL improves outcomes for standard risk patients: results of JACLS ALL-02. Hasegawa D, Imamura T, Yumura-Yagi K, Takahashi Y, Usami I, Suenobu S, Nishimura S, Suzuki N, Hashii Y, Deguchi T, Saito A, Kato K, Kosaka Y, Hirayama M, Iguchi A, Kawasaki H, Hori H, Sato A, Toru T, Nakahata T, Oda M, Hara J, and Horibe K, for the Japan Association of Childhood Leukemia Study Group (JACLS). Blood Cancer J. 2020 Feb 27;10(2):23. doi: 10.1038/s41408-020-0287-4.


Hematopoietic stem cell transplantation for pediatric acute promyelocytic leukemia in Japan. Yamamoto S, Tomizawa D, Kudo K, Hasegawa D, Taga T, Yanada M, Kondo T, Nakazawa Y, Eto T, Inoue M, Kato K, Atsuta Y, Ishida H. Pediatr Blood Cancer. 2020 Jan 21:e28181. doi: 10.1002/pbc.28181.


A Multicenter, Open-label, Clinical Trial to Assess the Effectiveness and Safety of Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-intensity Conditioning in Relapsed/refractory Anaplastic Large-cell Lymphoma in Children. Kada A, Fukano R, Mori T, Kamei M, Tanaka F, Ueyama J, Sekimizu M, Osumi T, Mori T, Koga Y, Ohki K, Fujita N, Mitsui T, Saito AM, Hashimoto H, Kobayashi R. Acta Med Okayama. 2020 Feb;74(1):89-94. doi: 10.18926/AMO/57959.


Level of seven neuroblastoma-associated mRNAs detected by droplet digital PCR is associated with tumor relapse/regrowth of high-risk neuroblastoma patients. Thwin KKM, Ishida T, Uemura S, Yamamoto N, Lin KS, Tamura A, Kozaki A, Saito A, Kishimoto K, Mori T, Hasegawa D, Kosaka Y, Nino N, Takafuji S, Iijima K, Nishimura N.J Mol Diagn. 2020 Feb;22(2):236-246. doi: 10.1016/j.jmoldx.2019.10.012.


Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L-asparaginase induction therapy in pediatric acute lymphoblastic leukemia. Ishihara T, Nogami K, Ochi S, Ishida T, Kosaka Y, Sawada A, Inoue M, Osone S, Imamura T, Hosoi H, Shima M. Pediatr Blood Cancer. 2020 Jan;67(1):e28016. doi: 10.1002/pbc.28016. Epub 2019 Sep 25.


Clinical characteristics, treatment, and survival outcome in a cohort of pediatric patients with atypical teratoid/rhabdoid tumor: a retrospective study by the Japan Children's Cancer Group. Yamasaki K, Kiyotani C, Terashima K, Watanabe Y, Kanamori M, Koga Y, Hata N, Iwasaki F, Goto H, Koh K, Kurihara J, Tokunaga S, Arakawa Y, Hasegawa D, Kosaka Y, Hara J. Journal of Neurosurgery: Pediatrics 2019 Nov 15:1-10. doi: 10.3171/2019.9.PEDS19367.


Hematopoietic stem cell transplantation in solid organ recipients with emphasis on transplant complications: a nationwide retrospective survey on behalf of the JSHCT, transplant complications working group. Shinohara A, Oshima K, Fuji S, Umeda K, Kako S, Kurokawa M, Tsukada N, Kasai M, Kondo T, Hashii Y, Nakamae H, Ikegame K, Kosaka Y, Shimada A, Nawa Y, Makoto Y, Yoshiko A, Fukuda T, Tanaka J, Ogata M.Biol Blood Marrow Transplant. 2020 Jan;26(1):66-75. doi: 10.1016/j.bbmt.2019.08.021. Epub 2019 Sep 5

―2019年―


Clinical outcomes after allogeneic hematopoietic stem cell transplantation in children with juvenile myelomonocytic leukemia: A report from the Japan Society for Hematopoietic Cell Transplantation. Yoshida N, Sakaguchi H, Yabe M, Hasegawa D, Hama A, Hasegawa D, Kato M, Noguchi M, Terui K, Takahashi Y, Cho Y, Sato M, Koh K, Kakuda H, Shimada H, Hashii Y, Sato A, Kato K, Atsuta Y, Watanabe K; Pediatric Myelodysplastic Syndrome Working Group of the Japan Society for Hematopoietic Cell Transplantation.Biol Blood Marrow Transplant. 2019 Nov 29. pii: S1083-8791(19)30835-3. doi: 10.1016/j.bbmt.2019.11.029.


Clinical practice recommendations for the diagnosis and management of human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation: the Japan Society of Hematopoietic Cell Transplantation". Ogata M, Uchida N, Fukuda T, Ikegame K, Kamimura T, Onizuka M, Kato K, Kobayashi H, Sasahara Y, Sawa M, Sawada A, Hasegawa D, Masuko M, Miyamoto T. Bone Marrow Transplant. 2019 Nov 19. doi: 10.1038/s41409-019-0752-5.


A deep intronic mutation of c.1166-285 T > G in SLC46A1 is shared by four unrelated Japanese patients with hereditary folate malabsorption (HFM). Tozawa Y, Abdrabou SSMA, Nogawa-Chida N, Nishiuchi R, Ishida T, Suzuki Y, Sano H, Kobayashi R, Kishimoto K, Ohara O, Imai K, Naruto T, Kobayashi K, Ariga T, Yamada M. Clin Immunol. 2019 Sep 5;208:108256.


Vitamin B12 deficiency anemia in an exclusively breastfed infant born to an ileum-resected mother. Tamura A, Nino N, Yamamoto N, Ichikawa T, Naito A, Nakatani N, Nakamura S, Saito A, Kozaki A, Kousaku Matsubara K, Kishimoto K, Ishida T, Shigematsu Y, Hasegawa D, Kosaka Y. Pediatr Neonatol. 2019 Oct;60(5):579-580.


Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation. Nakano Y, Hasegawa D, Stewart DR, Schultz KAP, Harris AK, Hirato J, Uemura S, Tamura A, Saito A, Kawamura A, Yoshida M, Yamasaki K, Yamashita S, Ushijima T, Kosaka Y, Ichimura K, Dehner LP and D. Ashley Hill. Modern Pathology, 2019 Jul 11. doi: 10.1038/s41379-019-0319-4.


Dynamics of Minimal Residual Disease in Neuroblastoma Patients. Review. Uemura S, Ishida T, Kyae Mon Thwin K, Yamamoto N, Tamura A, Kishimoto K, Hasegawa D, Kosaka Y, Nino N, San Lin K, Takafuji T, Mori T, Iijima I, and Nishimura N. Front Oncol 2019 Jun 4;9:455. doi: 10.3389/fonc.2019.00455.


Predisposing factors and mortality in proven and probable invasive fungal disease in a pediatric referral center: a 5-year experience. Kishimoto K, Kasai M, Kawamura N, Ito Y, Yoshida M, Hasegawa D, Kawasaki K, Kosaka Y. World J Pediatr. 2019 Jun;15(3):270-275.


Robust programmed cell death-1 expression in a subset of Ewing sarcoma in contrast to Ewing-like sarcoma. Tamura A, Yoshida M, Yamamoto N, Nino N, Ichikawa T, Nakatani N, Nakamura S, Saito A, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Kosaka Y. Clinic in Oncology 2019. 4(1586): 1-4.


Early posttransplant plasma ADAMTS13 activity changes in stem cell transplantation: a prospective study in 46 pediatric patients. Bone Marrow Transplant. Kishimoto K, Hasegawa D, Kawasaki K, Tamura A, Yamamoto N, Saito A, Kozaki A, Ishida T, Kosaka Y. Bone Marrow Transplant. 2019 Mar 19. doi: 10.1038/s41409-019-0506-4.


Pazopanib maintenance therapy after tandem high-dose chemotherapy for disseminated Ewing sarcoma. Tamura A, Yamamoto N, Nino N, Ichikawa T, Nakatani N, Nakamura S, Saito A, Kozaki A, Kishimoto K, Ishida T, Yoshida M, Akasaka Y, Hasegawa D, Kosaka Y. Int Cancer Conf J. 2019 Feb 14;8(3):95-100.


Comparison of conditioning regimens for autologous stem cell transplantation in children with acute myeloid leukemia: A nationwide retrospective study in Japan. Sakaguchi H, Muramatsu H, Hasegawa D, Kudo K, Ishida H, Yoshida N, Koh K, Noguchi M, Shiba N, Tokimasa S, Fukuda T, Goto H, Miyamura T, Nakazawa Y, Hashii Y, Inoue M, Atsuta Y; Pediatric AML Working Group of the Japan Society for Hematopoietic Cell Transplantation. Pediatr Blood Cancer. 2019 Jan;66(1):e27459.


Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia. Usami I, Imamura T, Takahashi Y, Suenobu SI, Hasegawa D, Hashii Y, Deguchi T, Hori T, Shimada A, Kato K, Ito E, Moriya-Saito A, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Sato A, Horibe K; Japan Association of Childhood Leukemia Study Group (JACLS). Int J Hematol. 2019 Apr;109(4):477-482. doi: 10.1007/s12185-019-02599-w.


Prognostic analysis of pediatric acute megakaryoblastic leukemia by chimeric fusion genes screening. Tamefusa K, Fukutake K, Ishida H, Tamura A, Endo M, Hamamoto K, Koga Y, Yamada M, Kanamitsu K, Fujiwara K, Washio K, Shimada A. Rinsho Ketsueki. 2019;60(2):99-105.

―2018年―


Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 1. Allergy, Asthma & Clinical Immunology. Tamura A, Uemura S, Yamamoto N, Saito A, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Hiroki H, Okano T, Imai K, Morio T, Kanegane H, Kosaka Y. Allergy Asthma Clin Immunol. 2018 Nov 14;14:82.


Impact of Adjuvant Lorazepam with Granisetron on Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients with Acute Lymphoblastic Leukemia. Ono A, Kishimoto K, Hasegawa D, Goldman R, Kosaka Y. Support Care Cancer 2018 Jul 31. doi: 10.1007/s00520-018-4377-9.


Co-occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death. Tamura A, Uemura S, Matsubara K, Kozuki E, Tanaka T, Nino N, Yokoi1 T, Saito A, Ishida T, Hasegawa D, Umeki I, Niihori T, Nakazawa Y, Koike K, Aoki Y, and Kosaka Y. Clinical Case Reports 2018 May 8;6(7):1202-1207.


Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan. Taga T, Imamura T, Nakashima K, Maeda N, Watanabe A, Miyajima Y, Sakaguchi S, Sano H, Hasegawa D, Kawasaki H, Adachi S, Takagi M, Koh K, Manabe A, Taki T, Ishida Y. Int J Hematol. 2018 Oct;108(4):438-442.


Low-dose azacitidine maintenance therapy after allogeneic stem cell transplantation for high-risk pediatric acute myeloid leukemia. Tamura A, Ishida T, Saito A, Yamamoto N, Yokoi T, Uemura S, Nino N, Fujiwata T, Tahara T, Nakamura S, Kosaki A, Kenji K, Hasegawa D, Kosaka Y. Pediatr Blood Cancer. 2018 Jun 12:e27284.


Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study. Morimoto A, Shioda Y, Imamura T, Kudo K, Kitoh T, Kawaguchi H, Goto H, Kosaka Y, Tsunematsu Y, Imashuku S; Japan LCH Study Group. Int J Hematol. 2018 Aug;108(2):192-198.


Human CD134 (OX40) expressed on T cells plays a key role for human herpesvirus 6B replication after allogeneic hematopoietic stem cell transplantation. Nagamata S, Nagasaka M, Kawabata A, Kishimoto K, Hasegawa D, Kosaka Y, Mori T, Morioka I, Nishimura N, Iijima K, Yamada H, Kawamoto S, Yakushijin K, Matsuoka H, Mori Y. J Clin Virol. 2018 Feb 21;102:50-55.


Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. Uemura S, Tamura A, Yamamoto N, Saito A, Nakamura S, Fujiwara T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Muraosa Y, Kamei K, Kosaka Y. Pediatr Infect Dis J. 2018 Feb 12.


Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. Sakamoto K, Imamura T, Kihira K, Suzuki K, Ishida H, Morita H, Kanno M, Mori T, Hiramatsu H, Matsubara K, Terui K, Takahashi Y, Suenobu SI, Hasegawa D, Kosaka Y, Kato K, Moriya-Saito A, Sato A, Kawasaki H, Yumura-Yagi K, Hara J, Hori H, Horibe K. J Clin Oncol. 2018 Mar 20;36(9):900-907.


Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study. Shimada A, Iijima-Yamashita Y, Tawa A, Tomizawa D, Yamada M, Norio S, Watanabe T, Taga T, Iwamoto S, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Saito AM, Kiyokawa N, Horibe K, Hara Y, Oki K, Hayashi Y, Tanaka S, Adachi S. Int J Hematol. 2018 May;107(5):586-595.


ETV6-ABL1 fusion combined with monosomy 7 in childhood B-precursor acute lymphoblastic leukemia. Uemura S, Nishimura N, Hasegawa D, Shono A, Sakaguchi K, Matsumoto H, Nakamachi Y, Saegusa J, Yokoi T, Tahara T, Tamura A, Yamamoto N, Saito A, Kozaki A, Kishimoto K, Ishida T, Nino N, Takafuji S, Mori T, Iijima K, Kosaka Y. Int J Hematol. 2018 May;107(5):604-609.


Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia. Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H. Int J Hematol. 2018 Feb;107(2):201-210.


Successful Treatment of Transplantation-associated Atypical Hemolytic Uremic Syndrome With Eculizumab. Hasegawa D, Saito A, Nino N, Uemura S, Takafuji S, Yokoi T, Kozaki A, Ishida T, Kawasaki K, Yasumi T, Sakata N, Ohtsuka Y, Hirase S, Mori T, Nishimura N, Kusumoto M, Ogawa Y, Tominaga K, Nakagawa T, Kanda K, Tanaka R, Kosaka Y. J Pediatr Hematol Oncol. 2018 Jan;40(1):e41-e44.

―2017年―


Clinical significance of SH2B3 (LNK) expression in paediatric B-cell precursor acute lymphoblastic leukaemia. Yano M, Imamura T, Asai D, Deguchi T, Hashii Y, Endo M, Sato A, Kawasaki H, Kosaka Y, Kato K, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K. Br J Haematol. 2017 Oct 29.


Fludarabine, cytarabine, granulocyte colony-stimulating factor and idarubicin for relapsed childhood acute myeloid leukemia. Nakayama H, Tomizawa D, Tanaka S, Iwamoto S, Shimada A, Saito AM, Yamashita Y, Moritake H, Terui K, Taga T, Matsuo H, Kosaka Y, Koh K, Hosoi H, Kurosawa H, Isoyama K, Horibe K, Mizutani S, Adachi S. Pediatr Int. 2017 Oct;59(10):1046-1052.


Reemergence of translocation t(11;19)(q23;p13.1) in the absence of clinically overt leukemia. Uemura S, Tamura A, Saito A, Hasegawa D, Nino N, Yokoi T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Kawasaki K, Mori T, Nishimura N, Ishimae M, Eguchi M, Kosaka Y. Int J Hematol. 2017 Dec;106(6):847-851.


Congenital immature pure erythroid leukemia with E-cadherin expression. Tamura A, Uemura S, Saito A, Okubo S, Nino N, Tahara T, Yokoi T, Kishimoto K, Ishida T, Hasegawa D, Kawasaki K, Yoshimoto S, Nakao H, Yoshida M, Kosaka Y. Int J Hematol. 2017 Nov;106(5):711-717.


Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma. Matsumoto K, Shichino H, Kawamoto H, Kosaka Y, Chin M, Kato K, Mugishima H. Pediatr Blood Cancer. 2017 Nov;64(11).


C/EBPβ is required for survival of Ly6C- monocytes. Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Tenen DG, Maekawa T. Blood. 2017 Oct 19;130(16):1809-1818.


Refractory double-hit lymphoma/leukemia in childhood mimicking B-precursor acute lymphoblastic leukemia at initial presentation. Uemura S, Hasegawa D, Yokoi T, Nino N, Tahara T, Tamura A, Saito A, Kozaki A, Kishimoto K, Ishida T, Kawasaki K, Yamamoto N, Mori T, Nishimura N, Kosaka Y. Rinsho Ketsueki. 2017;58(2):143-149. Review.


Prevention of chemotherapy-induced vomiting in children receiving multiple-day cisplatin chemotherapy: A hospital-based, retrospective cohort study. Kishimoto K, Kawasaki K, Saito A, Kozaki A, Ishida T, Hasegawa D, Kosaka Y. Pediatr Blood Cancer. 2017 Sep;64(9).


Clinically Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion Accompanied by Epstein-Barr Virus Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature. Yamaguchi H, Ishida T, Yokoi T, Tanaka T, Maruyama A, Nagase H, Hasegawa D, Imadome KI, Takeda H, Kosaka Y, Uetani Y. J Pediatr Hematol Oncol. 2017 Mar;39(2):e92-e96. Review.


Long-term outcomes of 95 children with moderate aplastic anemia treated with horse antithymocyte globulin and cyclosporine. Nishikawa E, Yagasaki H, Hama A, Yabe H, Ohara A, Kosaka Y, Kudo K, Kobayashi R, Ohga S, Morimoto A, Watanabe KI, Yoshida N, Muramatsu H, Takahashi Y, Kojima S. Pediatr Blood Cancer. 2017 May;64(5).


Predictive factor for intraoperative tumor rupture of Wilms tumor. Fukuzawa H, Shiima Y, Mishima Y, Sekine S, Miura S, Yabe K, Yamaki S, Morita K, Okata Y, Hisamatsu C, Nakao M, Yokoi A, Maeda K, Kosaka Y. Pediatr Surg Int. 2017 Jan;33(1):91-95.

―2016年―


Comparison of Donor Sources in Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Nationwide Retrospective Study. Sakaguchi H, Watanabe N, Matsumoto K, Yabe H, Kato S, Ogawa A, Inagaki J, Goto H, Koh K, Yoshida N, Kato K, Cho Y, Kosaka Y, Takahashi Y, Inoue M, Kato K, Atsuta Y, Miyamura K; Donor/Source Working Group of Japan Society of Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 Dec;22(12):2226-2234.


Early detection of tumor relapse/regrowth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients. Hirase S, Saitoh A, Hartomo TB, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Yamamoto N, Mori T, Hayakawa A, Iijima K, Nishio H, Nishimura N. Oncol Lett. 2016 Aug;12(2):1119-1123.


Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development. Hashimoto O, Yoshida M, Koma Y, Yanai T, Hasegawa D, Kosaka Y, Nishimura N, Yokozaki H. J Pathol. 2016 Oct;240(2):211-23.


IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance. Imamura T, Yano M, Asai D, Moriya-Saito A, Suenobu SI, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Horibe K, Sato A. Leukemia. 2016 Aug;30(8):1801-3.


Successful non-myeloablative allogenic bone marrow transplantation in a child with severe congenital neutropenia complicated by chronic pulmonary infection. Nino N, Kozaki A, Hasegawa D, Ueda G, Takahashi H, Miyata K, Ochi S, Yamashita T, Takafuji S, Uemura S, Yokoi T, Saito A, Ishida T, Kawasaki K, Nakamura K, Kobayashi M, Kosaka Y. Rinsho Ketsueki. 2016 Jun;57(6):742-7.


JAK2, MPL, and CALR mutations in children with essential thrombocythemia. Sekiya Y, Okuno Y, Muramatsu H, Ismael O, Kawashima N, Narita A, Wang X, Xu Y, Hama A, Fujisaki H, Imamura T, Hasegawa D, Kosaka Y, Sunami S, Ohtsuka Y, Ohga S, Takahashi Y, Kojima S, Shimada A. Int J Hematol. 2016 Aug;104(2):266-7.


Medulloblastoma with suprasellar solitary massive metastasis: Case report. Nagashima H, Nagashima T, Kawamura A, Yamamoto K, Yoshida M, Hasegawa D, Kosaka Y, Kohmura E. Neurol Neurochir Pol. 2016;50(3):211-4.


High event-free survival rate with minimum-dose-anthracycline treatment in childhood acute promyelocytic leukaemia: a nationwide prospective study by the Japanese Paediatric Leukaemia/Lymphoma Study Group. Takahashi H, Watanabe T, Kinoshita A, Yuza Y, Moritake H, Terui K, Iwamoto S, Nakayama H, Shimada A, Kudo K, Taki T, Yabe M, Matsushita H, Yamashita Y, Koike K, Ogawa A, Kosaka Y, Tomizawa D, Taga T, Saito AM, Horibe K, Nakahata T, Miyachi H, Tawa A, Adachi S. Br J Haematol. 2016 Aug;174(3):437-43.

―2015年―


Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients. Yamamoto N, Kozaki A, Hartomo TB, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Hirase S, Mori T, Hayakawa A, Iijima K, Nishio H, Nishimura N. Oncol Lett. 2015 Nov;10(5):3228-3232.


Randomized study of granulocyte colony stimulating factor for childhood B-cell non-Hodgkin lymphoma: a report from the Japanese pediatric leukemia/lymphoma study group B-NHL03 study. Tsurusawa M, Watanabe T, Gosho M, Mori T, Mitsui T, Sunami S, Kobayashi R, Fukano R, Tanaka F, Fujita N, Inada H, Sekimizu M, Koh K, Kosaka Y, Komada Y, Saito AM, Nakazawa A, Horibe K; lymphoma committee of the Japanese Pediatric Leukemia/lymphoma Study Group. Leuk Lymphoma. 2016 Jul;57(7):1657-64.


Absolute lymphocyte count at the end of induction therapy is a prognostic factor in childhood acute lymphoblastic leukemia. Hirase S, Hasegawa D, Takahashi H, Moriwaki K, Saito A, Kozaki A, Ishida T, Yanai T, Kawasaki K, Yamamoto N, Kubokawa I, Mori T, Hayakawa A, Nishimura N, Nishio H, Iijima K, Kosaka Y. Int J Hematol. 2015 Nov;102(5):594-601.


Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. Yano M, Imamura T, Asai D, Kiyokawa N, Nakabayashi K, Matsumoto K, Deguchi T, Hashii Y, Honda YK, Hasegawa D, Sasahara Y, Ishii M, Kosaka Y, Kato K, Shima M, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K, Ichikawa H, Sato A. Br J Haematol. 2015 Dec;171(5):813-7.


Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. Yoshida H, Imamura T, Saito AM, Takahashi Y, Suenobu S, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Endo M, Hori H, Suzuki N, Kosaka Y, Kato K, Yumura-Yagi K, Hara J, Oda M, Sato A, Horibe K; Japan Association of Childhood Leukemia Study.PLoS One. 2015 Aug 28;10(8):e0136428.


Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine. Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S. Haematologica. 2015 Nov;100(11):1426-33.


Familial Hemophagocytic Lymphohistiocytosis Presenting as Hydrops Fetalis. Iwatani S, Uemura K, Mizobuchi M, Yoshimoto S, Kawasaki K, Kosaka Y, Hori M, Yasumi T, Nakao H. AJP Rep. 2015 Apr;5(1):e22-4.


Congenital mesoblastic nephroma with focal anaplastic lesion. Yoshida M, Okita H, Tanimoto T, Bitoh Y, Fukuzawa H, Yokoi A, Kozaki A, Kawasaki K, Akasaka Y. Pathol Int. 2015 Sep;65(9):507-9.


Pharmacokinetics, efficacy, and safety of caspofungin in Japanese pediatric patients with invasive candidiasis and invasive aspergillosis. Mori M, Imaizumi M, Ishiwada N, Kaneko T, Goto H, Kato K, Hara J, Kosaka Y, Koike K, Kawamoto H, Maeda N, Yoshinari T, Kishino H, Takahashi K, Kawahara S, Kartsonis NA, Komada Y. J Infect Chemother. 2015 Jun;21(6):421-6.


Comparison of transplantation with reduced and myeloablative conditioning for children with acute lymphoblastic leukemia. Kato K, Kato M, Hasegawa D, Kawasaki H, Ishida H, Okamoto Y, Koh K, Inoue M, Inagaki J, Kato K, Sakamaki H, Yabe H, Kawa K, Suzuki R, Atsuta Y. Blood. 2015 Feb 19;125(8):1352-4.


Mutations in Bruton's tyrosine kinase impair IgA responses. Mitsuiki N, Yang X, Bartol SJ, Grosserichter-Wagener C, Kosaka Y, Takada H, Imai K, Kanegane H, Mizutani S, van der Burg M, van Zelm MC, Ohara O, Morio T. Int J Hematol. 2015 Mar;101(3):305-13.


Comparison of a fludarabine and melphalan combination-based reduced toxicity conditioning with myeloablative conditioning by radiation and/or busulfan in acute myeloid leukemia in Japanese children and adolescents. Ishida H, Adachi S, Hasegawa D, Okamoto Y, Goto H, Inagaki J, Inoue M, Koh K, Yabe H, Kawa K, Kato K, Atsuta Y, Kudo K. Pediatr Blood Cancer. 2015 May;62(5):883-9.


Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma. Hartomo TB, Van Huyen Pham T, Yamamoto N, Hirase S, Hasegawa D, Kosaka Y, Matsuo M, Hayakawa A, Takeshima Y, Iijima K, Nishio H, Nishimura N. Int J Oncol. 2015 Mar;46(3):1089-98.



連絡先 連絡先:兵庫県立こども病院 血液・腫瘍内科
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