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血液・腫瘍内科

対象疾患と診療実績

対象疾患

血液疾患: 白血病、悪性リンパ腫、再生不良性貧血、骨髄異形成症候群、血球貪食症候群、ランゲルハンス細胞組織球症、血友病など
固形腫瘍:神経芽腫、肝芽腫、ウィルムス腫瘍、横紋筋肉腫、網膜芽腫、脳腫瘍、骨軟部腫瘍など
その他すべての悪性腫瘍、先天性免疫不全症など

日本小児がん研究グループ(JCCG)に所属しており、基本的には白血病、悪性リンパ腫、各種固形腫瘍等については多施設共同研究の成果に基づいた同グループの定める全国共通のプロトコールで治療を行なっています。


診療実績

2014年の新規症例数は165例(うち白血病・神経芽腫等の悪性腫瘍は76例)で全国でも有数の症例数を誇っています。難治例については造血細胞移植も考慮します。
専用の完全無菌室2床を用い(新病院では4床に増床)、2009年以降は概ね年間20例前後の移植を施行しています。
当院では2003年に骨髄移植推進財団および日本さい帯血バンクネットワークの移植認定施設となりましたが、これ以降の移植件数は延べ211件です。




業績


業績


―2018年―


Impact of Adjuvant Lorazepam with Granisetron on Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients with Acute Lymphoblastic Leukemia. Ono A, Kishimoto K, Hasegawa D, Goldman R, Kosaka Y. Support Care Cancer 2018 in press.


Co-occurrence of hypertrophic cardiomyopathy and juvenile myelomonocytic leukemia in a neonate with Noonan syndrome, leading to premature death. Tamura A, Uemura S, Matsubara K, Kozuki E, Tanaka T, Nino N, Yokoi1 T, Saito A, Ishida T, Hasegawa D, Umeki I, Niihori T, Nakazawa Y, Koike K, Aoki Y, and Kosaka Y. Clinical Case Reports 2018 May 8;6(7):1202-1207.


Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan. Taga T, Imamura T, Nakashima K, Maeda N, Watanabe A, Miyajima Y, Sakaguchi S, Sano H, Hasegawa D, Kawasaki H, Adachi S, Takagi M, Koh K, Manabe A, Taki T, Ishida Y. Int J Hematol. 2018 Jul 3.


Low-dose azacitidine maintenance therapy after allogeneic stem cell transplantation for high-risk pediatric acute myeloid leukemia. Tamura A, Ishida T, Saito A, Yamamoto N, Yokoi T, Uemura S, Nino N, Fujiwata T, Tahara T, Nakamura S, Kosaki A, Kenji K, Hasegawa D, Kosaka Y. Pediatr Blood Cancer. 2018 Jun 12:e27284.


Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study. Morimoto A, Shioda Y, Imamura T, Kudo K, Kitoh T, Kawaguchi H, Goto H, Kosaka Y, Tsunematsu Y, Imashuku S; Japan LCH Study Group. Int J Hematol. 2018 Aug;108(2):192-198.


Human CD134 (OX40) expressed on T cells plays a key role for human herpesvirus 6B replication after allogeneic hematopoietic stem cell transplantation. Nagamata S, Nagasaka M, Kawabata A, Kishimoto K, Hasegawa D, Kosaka Y, Mori T, Morioka I, Nishimura N, Iijima K, Yamada H, Kawamoto S, Yakushijin K, Matsuoka H, Mori Y. J Clin Virol. 2018 Feb 21;102:50-55.


Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. Uemura S, Tamura A, Yamamoto N, Saito A, Nakamura S, Fujiwara T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Muraosa Y, Kamei K, Kosaka Y. Pediatr Infect Dis J. 2018 Feb 12.


Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. Sakamoto K, Imamura T, Kihira K, Suzuki K, Ishida H, Morita H, Kanno M, Mori T, Hiramatsu H, Matsubara K, Terui K, Takahashi Y, Suenobu SI, Hasegawa D, Kosaka Y, Kato K, Moriya-Saito A, Sato A, Kawasaki H, Yumura-Yagi K, Hara J, Hori H, Horibe K. J Clin Oncol. 2018 Mar 20;36(9):900-907.


Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study. Shimada A, Iijima-Yamashita Y, Tawa A, Tomizawa D, Yamada M, Norio S, Watanabe T, Taga T, Iwamoto S, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Saito AM, Kiyokawa N, Horibe K, Hara Y, Oki K, Hayashi Y, Tanaka S, Adachi S. Int J Hematol. 2018 May;107(5):586-595.


ETV6-ABL1 fusion combined with monosomy 7 in childhood B-precursor acute lymphoblastic leukemia. Uemura S, Nishimura N, Hasegawa D, Shono A, Sakaguchi K, Matsumoto H, Nakamachi Y, Saegusa J, Yokoi T, Tahara T, Tamura A, Yamamoto N, Saito A, Kozaki A, Kishimoto K, Ishida T, Nino N, Takafuji S, Mori T, Iijima K, Kosaka Y. Int J Hematol. 2018 May;107(5):604-609.


Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia. Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H. Int J Hematol. 2018 Feb;107(2):201-210.


Successful Treatment of Transplantation-associated Atypical Hemolytic Uremic Syndrome With Eculizumab. Hasegawa D, Saito A, Nino N, Uemura S, Takafuji S, Yokoi T, Kozaki A, Ishida T, Kawasaki K, Yasumi T, Sakata N, Ohtsuka Y, Hirase S, Mori T, Nishimura N, Kusumoto M, Ogawa Y, Tominaga K, Nakagawa T, Kanda K, Tanaka R, Kosaka Y. J Pediatr Hematol Oncol. 2018 Jan;40(1):e41-e44.

―2017年―


Clinical significance of SH2B3 (LNK) expression in paediatric B-cell precursor acute lymphoblastic leukaemia. Yano M, Imamura T, Asai D, Deguchi T, Hashii Y, Endo M, Sato A, Kawasaki H, Kosaka Y, Kato K, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K. Br J Haematol. 2017 Oct 29.


Fludarabine, cytarabine, granulocyte colony-stimulating factor and idarubicin for relapsed childhood acute myeloid leukemia. Nakayama H, Tomizawa D, Tanaka S, Iwamoto S, Shimada A, Saito AM, Yamashita Y, Moritake H, Terui K, Taga T, Matsuo H, Kosaka Y, Koh K, Hosoi H, Kurosawa H, Isoyama K, Horibe K, Mizutani S, Adachi S. Pediatr Int. 2017 Oct;59(10):1046-1052.


Reemergence of translocation t(11;19)(q23;p13.1) in the absence of clinically overt leukemia. Uemura S, Tamura A, Saito A, Hasegawa D, Nino N, Yokoi T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Kawasaki K, Mori T, Nishimura N, Ishimae M, Eguchi M, Kosaka Y. Int J Hematol. 2017 Dec;106(6):847-851.


Congenital immature pure erythroid leukemia with E-cadherin expression. Tamura A, Uemura S, Saito A, Okubo S, Nino N, Tahara T, Yokoi T, Kishimoto K, Ishida T, Hasegawa D, Kawasaki K, Yoshimoto S, Nakao H, Yoshida M, Kosaka Y. Int J Hematol. 2017 Nov;106(5):711-717.


Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma. Matsumoto K, Shichino H, Kawamoto H, Kosaka Y, Chin M, Kato K, Mugishima H. Pediatr Blood Cancer. 2017 Nov;64(11).


C/EBPβ is required for survival of Ly6C- monocytes. Tamura A, Hirai H, Yokota A, Kamio N, Sato A, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Tenen DG, Maekawa T. Blood. 2017 Oct 19;130(16):1809-1818.


Refractory double-hit lymphoma/leukemia in childhood mimicking B-precursor acute lymphoblastic leukemia at initial presentation. Uemura S, Hasegawa D, Yokoi T, Nino N, Tahara T, Tamura A, Saito A, Kozaki A, Kishimoto K, Ishida T, Kawasaki K, Yamamoto N, Mori T, Nishimura N, Kosaka Y. Rinsho Ketsueki. 2017;58(2):143-149. Review.


Prevention of chemotherapy-induced vomiting in children receiving multiple-day cisplatin chemotherapy: A hospital-based, retrospective cohort study. Kishimoto K, Kawasaki K, Saito A, Kozaki A, Ishida T, Hasegawa D, Kosaka Y. Pediatr Blood Cancer. 2017 Sep;64(9).


Clinically Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion Accompanied by Epstein-Barr Virus Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature. Yamaguchi H, Ishida T, Yokoi T, Tanaka T, Maruyama A, Nagase H, Hasegawa D, Imadome KI, Takeda H, Kosaka Y, Uetani Y. J Pediatr Hematol Oncol. 2017 Mar;39(2):e92-e96. Review.


Long-term outcomes of 95 children with moderate aplastic anemia treated with horse antithymocyte globulin and cyclosporine. Nishikawa E, Yagasaki H, Hama A, Yabe H, Ohara A, Kosaka Y, Kudo K, Kobayashi R, Ohga S, Morimoto A, Watanabe KI, Yoshida N, Muramatsu H, Takahashi Y, Kojima S. Pediatr Blood Cancer. 2017 May;64(5).


Predictive factor for intraoperative tumor rupture of Wilms tumor. Fukuzawa H, Shiima Y, Mishima Y, Sekine S, Miura S, Yabe K, Yamaki S, Morita K, Okata Y, Hisamatsu C, Nakao M, Yokoi A, Maeda K, Kosaka Y. Pediatr Surg Int. 2017 Jan;33(1):91-95.

―2016年―


Comparison of Donor Sources in Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Nationwide Retrospective Study. Sakaguchi H, Watanabe N, Matsumoto K, Yabe H, Kato S, Ogawa A, Inagaki J, Goto H, Koh K, Yoshida N, Kato K, Cho Y, Kosaka Y, Takahashi Y, Inoue M, Kato K, Atsuta Y, Miyamura K; Donor/Source Working Group of Japan Society of Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 Dec;22(12):2226-2234.


Early detection of tumor relapse/regrowth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients. Hirase S, Saitoh A, Hartomo TB, Kozaki A, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Yamamoto N, Mori T, Hayakawa A, Iijima K, Nishio H, Nishimura N. Oncol Lett. 2016 Aug;12(2):1119-1123.


Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development. Hashimoto O, Yoshida M, Koma Y, Yanai T, Hasegawa D, Kosaka Y, Nishimura N, Yokozaki H. J Pathol. 2016 Oct;240(2):211-23.


IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance. Imamura T, Yano M, Asai D, Moriya-Saito A, Suenobu SI, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Horibe K, Sato A. Leukemia. 2016 Aug;30(8):1801-3.


Successful non-myeloablative allogenic bone marrow transplantation in a child with severe congenital neutropenia complicated by chronic pulmonary infection. Nino N, Kozaki A, Hasegawa D, Ueda G, Takahashi H, Miyata K, Ochi S, Yamashita T, Takafuji S, Uemura S, Yokoi T, Saito A, Ishida T, Kawasaki K, Nakamura K, Kobayashi M, Kosaka Y. Rinsho Ketsueki. 2016 Jun;57(6):742-7.


JAK2, MPL, and CALR mutations in children with essential thrombocythemia. Sekiya Y, Okuno Y, Muramatsu H, Ismael O, Kawashima N, Narita A, Wang X, Xu Y, Hama A, Fujisaki H, Imamura T, Hasegawa D, Kosaka Y, Sunami S, Ohtsuka Y, Ohga S, Takahashi Y, Kojima S, Shimada A. Int J Hematol. 2016 Aug;104(2):266-7.


Medulloblastoma with suprasellar solitary massive metastasis: Case report. Nagashima H, Nagashima T, Kawamura A, Yamamoto K, Yoshida M, Hasegawa D, Kosaka Y, Kohmura E. Neurol Neurochir Pol. 2016;50(3):211-4.


High event-free survival rate with minimum-dose-anthracycline treatment in childhood acute promyelocytic leukaemia: a nationwide prospective study by the Japanese Paediatric Leukaemia/Lymphoma Study Group. Takahashi H, Watanabe T, Kinoshita A, Yuza Y, Moritake H, Terui K, Iwamoto S, Nakayama H, Shimada A, Kudo K, Taki T, Yabe M, Matsushita H, Yamashita Y, Koike K, Ogawa A, Kosaka Y, Tomizawa D, Taga T, Saito AM, Horibe K, Nakahata T, Miyachi H, Tawa A, Adachi S. Br J Haematol. 2016 Aug;174(3):437-43.

―2015年―


Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients. Yamamoto N, Kozaki A, Hartomo TB, Yanai T, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Hirase S, Mori T, Hayakawa A, Iijima K, Nishio H, Nishimura N. Oncol Lett. 2015 Nov;10(5):3228-3232.


Randomized study of granulocyte colony stimulating factor for childhood B-cell non-Hodgkin lymphoma: a report from the Japanese pediatric leukemia/lymphoma study group B-NHL03 study. Tsurusawa M, Watanabe T, Gosho M, Mori T, Mitsui T, Sunami S, Kobayashi R, Fukano R, Tanaka F, Fujita N, Inada H, Sekimizu M, Koh K, Kosaka Y, Komada Y, Saito AM, Nakazawa A, Horibe K; lymphoma committee of the Japanese Pediatric Leukemia/lymphoma Study Group. Leuk Lymphoma. 2016 Jul;57(7):1657-64.


Absolute lymphocyte count at the end of induction therapy is a prognostic factor in childhood acute lymphoblastic leukemia. Hirase S, Hasegawa D, Takahashi H, Moriwaki K, Saito A, Kozaki A, Ishida T, Yanai T, Kawasaki K, Yamamoto N, Kubokawa I, Mori T, Hayakawa A, Nishimura N, Nishio H, Iijima K, Kosaka Y. Int J Hematol. 2015 Nov;102(5):594-601.


Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. Yano M, Imamura T, Asai D, Kiyokawa N, Nakabayashi K, Matsumoto K, Deguchi T, Hashii Y, Honda YK, Hasegawa D, Sasahara Y, Ishii M, Kosaka Y, Kato K, Shima M, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K, Ichikawa H, Sato A. Br J Haematol. 2015 Dec;171(5):813-7.


Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. Yoshida H, Imamura T, Saito AM, Takahashi Y, Suenobu S, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Endo M, Hori H, Suzuki N, Kosaka Y, Kato K, Yumura-Yagi K, Hara J, Oda M, Sato A, Horibe K; Japan Association of Childhood Leukemia Study.PLoS One. 2015 Aug 28;10(8):e0136428.


Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine. Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S. Haematologica. 2015 Nov;100(11):1426-33.


Familial Hemophagocytic Lymphohistiocytosis Presenting as Hydrops Fetalis. Iwatani S, Uemura K, Mizobuchi M, Yoshimoto S, Kawasaki K, Kosaka Y, Hori M, Yasumi T, Nakao H. AJP Rep. 2015 Apr;5(1):e22-4.


Congenital mesoblastic nephroma with focal anaplastic lesion. Yoshida M, Okita H, Tanimoto T, Bitoh Y, Fukuzawa H, Yokoi A, Kozaki A, Kawasaki K, Akasaka Y. Pathol Int. 2015 Sep;65(9):507-9.


Pharmacokinetics, efficacy, and safety of caspofungin in Japanese pediatric patients with invasive candidiasis and invasive aspergillosis. Mori M, Imaizumi M, Ishiwada N, Kaneko T, Goto H, Kato K, Hara J, Kosaka Y, Koike K, Kawamoto H, Maeda N, Yoshinari T, Kishino H, Takahashi K, Kawahara S, Kartsonis NA, Komada Y. J Infect Chemother. 2015 Jun;21(6):421-6.


Comparison of transplantation with reduced and myeloablative conditioning for children with acute lymphoblastic leukemia. Kato K, Kato M, Hasegawa D, Kawasaki H, Ishida H, Okamoto Y, Koh K, Inoue M, Inagaki J, Kato K, Sakamaki H, Yabe H, Kawa K, Suzuki R, Atsuta Y. Blood. 2015 Feb 19;125(8):1352-4.


Mutations in Bruton's tyrosine kinase impair IgA responses. Mitsuiki N, Yang X, Bartol SJ, Grosserichter-Wagener C, Kosaka Y, Takada H, Imai K, Kanegane H, Mizutani S, van der Burg M, van Zelm MC, Ohara O, Morio T. Int J Hematol. 2015 Mar;101(3):305-13.


Comparison of a fludarabine and melphalan combination-based reduced toxicity conditioning with myeloablative conditioning by radiation and/or busulfan in acute myeloid leukemia in Japanese children and adolescents. Ishida H, Adachi S, Hasegawa D, Okamoto Y, Goto H, Inagaki J, Inoue M, Koh K, Yabe H, Kawa K, Kato K, Atsuta Y, Kudo K. Pediatr Blood Cancer. 2015 May;62(5):883-9.


Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma. Hartomo TB, Van Huyen Pham T, Yamamoto N, Hirase S, Hasegawa D, Kosaka Y, Matsuo M, Hayakawa A, Takeshima Y, Iijima K, Nishio H, Nishimura N. Int J Oncol. 2015 Mar;46(3):1089-98.



連絡先 連絡先:兵庫県立こども病院 血液・腫瘍内科
住所:〒650-0047 神戸市中央区港島南町1丁目6-7
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